Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1210
2008
-
Mapping of interaction domains of putative telomere-binding proteins AtTRB1 and AtPOT1b from Arabidopsis thaliana
FEBS LETT, year: 2008, volume: 582, edition: 10
-
Metodika pro zjištění postzygotických bariér křižitelnosti u rodu Trifolium a získání mezidruhových hybridů
Year: 2008
-
Metody klasické a molekulární cytogenetiky v diagnostice mnohočetného myelomu
Klinická onkologie, year: 2008, volume: 21, edition: Supplement
-
Mnohočetný myelom
Hematologie: přehled maligních hematologických nemocí, edition: Vyd. 2., year: 2008, number of pages: 6 s.
-
Mobilní genetické elementy a jejich využití v diagnostice stafylokoků
Year: 2008, type: Conference abstract
-
Modulation of the antineoplastic effect of retinoids in neuroblastoma and medulloblastoma cell lines.
XIX. Biologické dny - Biologický výzkum pro lidské zdraví. Program a sborník abstrakt., year: 2008
-
Molecular analysis of repetitive elements in giant genomes of Fritillaria ( liliaceae)
Year: 2008, type: Conference abstract
-
Molecular diagnostics of temperate bacteriophages of <I>Staphylococcus aureus</I>
13th International Symposium on Staphylococci and Staphylococcal Infections, year: 2008
-
Molecular typing of the enterotoxin H-positive Staphylococcus aureus strains isolated from patients and foods in the Czech Republic
Pathophysiology of Staphylococci, year: 2008
-
Molekulární diagnostika mírných stafylokokových bakteriofágů
XVII. konference mladých mikrobiologů Tomáškovy dny 2008, year: 2008